| Ukraine | Geographical |
| U.S. Air Force (Careers) | General |
| U.S. Army (Careers) | General |
| U.S. Census | General, P.F. r312 |
| U.S. Coast Guard (Careers) | General |
| U.S. Congress | General |
| U.S. Constitution | P.F.342.7 |
| U. S. Defenses | General |
| U.S. Description & Travel Booklets - Midwest | P.F.917.3 |
| U.S. Description & Travel Booklets - Northeast | P.F.917.3 |
| U.S. Description & Travel Booklets - South | P.F.917.3 |
| U.S. Description & Travel Booklets - Southeast | P.F.917.3 |
| U.S. Description & Travel Booklets - West | P.F.917.3 |
| U.S. Foreign Relations | General |
| U.S. History | General,J Vertical File |
| U.S. History (Civil War) | P.F.973.7 |
| U.S. Marine Corps (Careers) | General |
| U.S. Navy (Careers) | General |
| U.S. Politics & Government | General |
| U.S. Postal Service (Westgate Branch) | Local History |
| U.S. Presidents | General |
| Uganda | Geographical |
| Ultralife Batteries Inc. of Newark | Business |
| Unique Staffing Services | Business |
| Unisys Corp. | Business |
| United Arab Emigrates | Geographical |
| United Dry Cleaning of Rochester, Inc | Business |
| United Kingdom (see England, Scotland Wales) | Geographical |
| United Nations | General |
| United States | Picture |
| United States (Maps, entire U.S.) | Geographical |
| United States (Regional Maps) | States |
| United States (Regional Maps - South) | States |
| United States (Territories and Possessions) | Geographical |
| United Way (Red Cross) | Local History |
| Universities & Colleges (Monroe County) | Local History |
| Universities & Colleges (New York State) | Local History |
| University of Rochester | Business |
| Upper Volta (see Burkina Faso) | |
| Urban Development | General |
| Uruguay | Geographical |
| Usbekistan | Geographical |
| Utah | States |
| Utilicom Inc. | Business |
| V.F.W. Veterans of Foreign Wars (Doud Post and Area) | Local History |
| Valley (The Genesee Valley Regional Magazine) | Local History |
| Vari-Care, Inc. | Business |
| Variety Store (Ceramic Packaging Inc.) | Business |
| VCRX Inc. | Business |
| Vehicare Corp. | Business |
| Venereal Diseases | General |
| Venezuela | Geographical |
| Vermont | States |
| Veterans - Monroe County | Local History |
| Veterans (U.S.) | General |
| Veterinarians | General |
| Video Tape Recorder & Recording | General |
| Vietnam | Geographical |
| Vietnam Veterans (Local Group) | Local History |
| Village Green Bookstore | Business |
| Virgilio, Andrew | Local History |
| Virgin Islands | Geographical |
| Virginia | States |
| Vital Statistics | General |
| Vital Statistics (Monroe County, see Census) | Local History |
| Viva Foam Corp. | Business |
| Vocational Guidance | General |
| Volt Delta Resources Inc. | Business |
| Voters | General |
